Assay Detail
Functional
CHEMBL993017
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Cytotoxicity against human QG56 cells after 4 days
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | QG-56 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.95 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL448144 | ECTEINASCIDIN 770 | — | 1 | 8.41 |
| CHEMBL452709 | SAFRAMYCIN A | — | 1 | 8.26 |
| CHEMBL510507 | RENIERAMYCIN N | — | 1 | 7.96 |
| CHEMBL451147 | RENIERAMYCIN M | — | 1 | 7.72 |
| CHEMBL503821 | RENIERAMYCIN O | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL448144 | ECTEINASCIDIN 770 | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL452709 | SAFRAMYCIN A | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL510507 | RENIERAMYCIN N | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL451147 | RENIERAMYCIN M | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL503821 | RENIERAMYCIN O | IC50 | = | 40.0 | nM | 7.40 |