Assay Detail
Functional
CHEMBL993038
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells after 3 days by SRB assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isolation and characterization of new epothilone analogues from recombinant Myxococcus xanthus fermentations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.01 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96172 | EPOTHILONE D | 2.0 | 1 | 7.80 |
| CHEMBL453818 | — | — | 1 | 7.33 |
| CHEMBL319648 | EPOTHILONE C | — | 1 | 7.01 |
| CHEMBL511398 | — | — | 1 | 6.60 |
| CHEMBL513476 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96172 | EPOTHILONE D | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL453818 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL319648 | EPOTHILONE C | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL511398 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL513476 | — | IC50 | = | 500.0 | nM | 6.30 |