Assay Detail
Functional
CHEMBL993040
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Cytotoxicity against human SF268 cells after 3 days by SRB assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SF-268 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isolation and characterization of new epothilone analogues from recombinant Myxococcus xanthus fermentations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.92 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96172 | EPOTHILONE D | 2.0 | 1 | 7.75 |
| CHEMBL453818 | — | — | 1 | 7.04 |
| CHEMBL319648 | EPOTHILONE C | — | 1 | 6.47 |
| CHEMBL511398 | — | — | 1 | 6.41 |
| CHEMBL513476 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96172 | EPOTHILONE D | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL453818 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL319648 | EPOTHILONE C | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL511398 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL513476 | — | IC50 | > | 1000.0 | nM | - |