Assay Detail
Binding
CHEMBL993110
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Carbonic anhydrase (CHEMBL5931) ↗| Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
Publication
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 6.44 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6633 | — | — | 1 | 7.82 |
| CHEMBL6705 | — | — | 1 | 7.08 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.08 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.01 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 6.99 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.97 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 6.97 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 6.96 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 6.96 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 6.96 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 6.94 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.92 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 6.91 |
| CHEMBL268439 | — | — | 1 | 6.91 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 6.88 |
| CHEMBL7146 | — | — | 1 | 6.81 |
| CHEMBL7087 | — | — | 1 | 6.79 |
| CHEMBL266026 | — | — | 1 | 6.78 |
| CHEMBL451332 | — | — | 1 | 6.78 |
| CHEMBL266240 | — | — | 1 | 6.77 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 6.65 |
| CHEMBL6724 | — | — | 1 | 6.61 |
| CHEMBL6753 | — | — | 1 | 6.44 |
| CHEMBL6853 | — | — | 1 | 6.41 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 6.36 |
| CHEMBL265674 | — | — | 1 | 6.35 |
| CHEMBL7092 | — | — | 1 | 6.34 |
| CHEMBL360356 | — | — | 1 | 6.25 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 6.18 |
| CHEMBL268177 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6633 | — | Ki | = | 15.1 | nM | 7.82 |
| CHEMBL6705 | — | Ki | = | 82.3 | nM | 7.08 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 82.6 | nM | 7.08 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 98.4 | nM | 7.01 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL118 | CELECOXIB | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL26 | SULPIRIDE | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL268439 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL77517 | INDISULAM | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL7146 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL7087 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL451332 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL266026 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL266240 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 223.0 | nM | 6.65 |
| CHEMBL6724 | — | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL6753 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL6853 | — | Ki | = | 389.0 | nM | 6.41 |
| CHEMBL419 | MAFENIDE | Ki | = | 433.0 | nM | 6.36 |
| CHEMBL265674 | — | Ki | = | 447.0 | nM | 6.35 |
| CHEMBL7092 | — | Ki | = | 457.0 | nM | 6.34 |
| CHEMBL360356 | — | Ki | = | 565.0 | nM | 6.25 |
| CHEMBL865 | VALDECOXIB | Ki | = | 654.0 | nM | 6.18 |
| CHEMBL268177 | — | Ki | = | 976.0 | nM | 6.01 |
| CHEMBL328560 | SULTHIAME | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL6784 | — | Ki | = | 7540.0 | nM | 5.12 |
| CHEMBL6919 | — | Ki | = | 8970.0 | nM | 5.05 |
| CHEMBL310671 | SACCHARIN | Ki | = | 12500.0 | nM | 4.90 |
| CHEMBL414 | CARZENIDE | Ki | = | 14500.0 | nM | 4.84 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 16100.0 | nM | 4.79 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 18500.0 | nM | 4.73 |