Assay Detail
Binding
CHEMBL993111
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PARP1
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 58 | 7.03 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481511 | — | — | 1 | 8.52 |
| CHEMBL370838 | — | — | 1 | 8.42 |
| CHEMBL370217 | — | — | 1 | 8.39 |
| CHEMBL196444 | — | — | 1 | 8.30 |
| CHEMBL196450 | — | — | 1 | 8.17 |
| CHEMBL195402 | — | — | 1 | 7.92 |
| CHEMBL251030 | — | — | 1 | 7.89 |
| CHEMBL401843 | — | — | 1 | 7.80 |
| CHEMBL195913 | — | — | 1 | 7.72 |
| CHEMBL371425 | — | — | 1 | 7.70 |
| CHEMBL399725 | — | — | 1 | 7.68 |
| CHEMBL251028 | — | — | 1 | 7.64 |
| CHEMBL433356 | — | — | 1 | 7.60 |
| CHEMBL480039 | — | — | 1 | 7.60 |
| CHEMBL479471 | — | — | 1 | 7.58 |
| CHEMBL479861 | — | — | 1 | 7.57 |
| CHEMBL371205 | — | — | 1 | 7.48 |
| CHEMBL371244 | — | — | 1 | 7.44 |
| CHEMBL510733 | — | — | 1 | 7.35 |
| CHEMBL480234 | — | — | 1 | 7.34 |
| CHEMBL381208 | — | — | 1 | 7.30 |
| CHEMBL196507 | — | — | 1 | 7.26 |
| CHEMBL372450 | — | — | 1 | 7.25 |
| CHEMBL480613 | — | — | 1 | 7.20 |
| CHEMBL425201 | — | — | 1 | 7.19 |
| CHEMBL519443 | — | — | 1 | 7.15 |
| CHEMBL443077 | — | — | 1 | 7.06 |
| CHEMBL519778 | — | — | 1 | 7.06 |
| CHEMBL381652 | — | — | 1 | 7.05 |
| CHEMBL425560 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481511 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL370838 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL370217 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL196444 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL196450 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL195402 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL251030 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL401843 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL195913 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL371425 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL399725 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL251028 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL433356 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL480039 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL479471 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL479861 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL371205 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL371244 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL510733 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL480234 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL381208 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL196507 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL372450 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL480613 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL425201 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL519443 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL519778 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL443077 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL381652 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL425560 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL481403 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL473036 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL481603 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL372303 | PJ34 | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL480227 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL481204 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL320031 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL521428 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL194482 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL196559 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL294060 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL520924 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL106154 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL322268 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL452100 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL452158 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL480452 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL480614 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL480615 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL480108 | — | IC50 | = | 299.0 | nM | 6.52 |