Assay Detail
Binding
CHEMBL993333
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Displacement of [3H]diprenorphine from human kappa opioid receptor in CHO cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.80 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494265 | — | — | 1 | 6.28 |
| CHEMBL494479 | — | — | 1 | 6.08 |
| CHEMBL492449 | — | — | 1 | 5.70 |
| CHEMBL25230 | — | — | 1 | 5.47 |
| CHEMBL492447 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494265 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL494479 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL492449 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL25230 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL492447 | — | Ki | = | 3400.0 | nM | 5.47 |