Assay Detail
Functional
CHEMBL993367
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Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.62 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78010 | PECTOLINARIGENIN | — | 1 | 5.25 |
| CHEMBL460387 | — | — | 1 | 5.13 |
| CHEMBL460388 | — | — | 1 | 4.88 |
| CHEMBL445978 | PECTOLINARIN | — | 1 | 4.41 |
| CHEMBL483758 | — | — | 1 | 4.35 |
| CHEMBL520682 | — | — | 1 | 4.22 |
| CHEMBL484937 | — | — | 1 | 4.07 |
| CHEMBL483757 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78010 | PECTOLINARIGENIN | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL460387 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL460388 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL445978 | PECTOLINARIN | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL483758 | — | IC50 | = | 44900.0 | nM | 4.35 |
| CHEMBL520682 | — | IC50 | = | 59900.0 | nM | 4.22 |
| CHEMBL484937 | — | IC50 | = | 85100.0 | nM | 4.07 |
| CHEMBL483757 | — | IC50 | > | 100000.0 | nM | - |