Assay Detail
Binding
CHEMBL993385
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Displacement of [3H]spiperone from human dopamine D2 receptor expressed in HEK293 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D(1) receptor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.11 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL520821 | — | — | 1 | 7.54 |
| CHEMBL484538 | — | — | 1 | 6.68 |
| CHEMBL503958 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL520821 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL484538 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL503958 | — | Ki | > | 10000.0 | nM | - |