Assay Detail
Binding
CHEMBL993554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cdc2/cyclin B assessed as [32P] incorporation in histone H1 from [gamma32P]ATP
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B1 (CHEMBL1907602) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.70 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23327 | PURVALANOLA | — | 1 | 8.40 |
| CHEMBL23254 | PURVALANOL B | — | 1 | 8.22 |
| CHEMBL311228 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23327 | PURVALANOLA | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL23254 | PURVALANOL B | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL311228 | — | IC50 | = | 340.0 | nM | 6.47 |