Assay Detail
Functional
CHEMBL993705
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at MCH1R expressed in CHO cells assessed as intracellular Ca2+ mobilization after 20 mins by FLIPR assay
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel approach for chemotype hopping based on annotated databases of chemically feasible fragments and a prospective case study: new melanin concentrating hormone antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.11 | 7.34 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL470633 | — | — | 1 | 7.34 |
| CHEMBL512873 | — | — | 1 | 7.08 |
| CHEMBL214957 | — | — | 2 | 7.05 |
| CHEMBL470840 | — | — | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL470633 | — | IC50 | = | 45.71 | nM | 7.34 |
| CHEMBL512873 | — | IC50 | = | 83.18 | nM | 7.08 |
| CHEMBL214957 | — | IC50 | = | 89.13 | nM | 7.05 |
| CHEMBL470840 | — | IC50 | = | 104.71 | nM | 6.98 |
| CHEMBL214957 | — | Activity | = | 87.0 | nM | - |