Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL993717

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of CK2 assessed as level of ATP utilized by luciferase-based bioluminescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives.
Wang RE, Kao JL, Hilliard CA, Pandita RK, Roti Roti JL, Hunt CR, Taylor JS.
J Med Chem (2009) 52 : 1912 -1921
PubMed 19296652 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.45 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL379064 ISORHAMNETIN 1 6.30
CHEMBL163316 3-O-METHYLQUERCETIN 1 6.08
CHEMBL503348 1 6.07
CHEMBL470635 1 5.61
CHEMBL50 QUERCETIN 3.0 1 5.25
CHEMBL312163 RHAMNETIN 1 5.01
CHEMBL512836 1 5.01
CHEMBL470634 1 4.28
CHEMBL226034 TAMARIXETIN 1 -
CHEMBL470848 1 -
CHEMBL470854 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL379064 ISORHAMNETIN IC50 = 500.0 nM 6.30
CHEMBL163316 3-O-METHYLQUERCETIN IC50 = 830.0 nM 6.08
CHEMBL503348 IC50 = 850.0 nM 6.07
CHEMBL470635 IC50 = 2450.0 nM 5.61
CHEMBL50 QUERCETIN IC50 = 5600.0 nM 5.25
CHEMBL312163 RHAMNETIN IC50 = 9700.0 nM 5.01
CHEMBL512836 IC50 = 9700.0 nM 5.01
CHEMBL470634 IC50 = 53000.0 nM 4.28
CHEMBL226034 TAMARIXETIN IC50 > 100000.0 nM -
CHEMBL470848 IC50 > 100000.0 nM -
CHEMBL470854 IC50 > 100000.0 nM -