Assay Detail
Binding
CHEMBL993810
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Inhibition of DNA polymerase beta lyase activity by deoxyribose phosphate excision assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
A new acylated oleanane triterpenoid from Couepia polyandra that inhibits the lyase activity of DNA polymerase beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.65 | 5.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 5.06 |
| CHEMBL502468 | — | — | 1 | 4.89 |
| CHEMBL221542 | BETA-SITOSTEROL | — | 1 | 4.58 |
| CHEMBL400247 | STIGMASTEROL | — | 1 | 4.36 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL502468 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL221542 | BETA-SITOSTEROL | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL400247 | STIGMASTEROL | IC50 | = | 43400.0 | nM | 4.36 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 43600.0 | nM | 4.36 |