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Assay Detail

CHEMBL993816

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Functional
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected erythrocytes by [3H]hypoxanthine uptake
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Enhancement of the antiplasmodial activity of quassin by transformation into a gamma-lactone.
Lang'at-Thoruwa C, Kirby GC, Phillipson JD, Warhurst DC, Watt RA, Wright CW.
J Nat Prod (2003) 66 : 1486 -1489
PubMed 14640524 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 6.02 6.02

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL513000 1 6.02
CHEMBL517016 QUASSIN 1 -
CHEMBL517757 NEOQUASSIN 1 -
CHEMBL468660 ANHYDROQUASSIN 1 -
CHEMBL501777 NEOQUASSIN ETHER 1 -
CHEMBL501691 1 -
CHEMBL467612 HYDROXYNEOQUASSINS 1 -
CHEMBL513326 1 -
CHEMBL467613 QUASSILACTOL 1 -
CHEMBL461393 QUASSILACTONE 1 -
CHEMBL58510 CHLOROQUINE PHOSPHATE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL513000 IC50 = 960.0 nM 6.02
CHEMBL517016 QUASSIN IC50 > 1000000.0 nM -
CHEMBL517757 NEOQUASSIN IC50 = 615000.0 nM -
CHEMBL468660 ANHYDROQUASSIN IC50 > 1000000.0 nM -
CHEMBL501777 NEOQUASSIN ETHER IC50 = 149000.0 nM -
CHEMBL501691 IC50 = 232000.0 nM -
CHEMBL467612 HYDROXYNEOQUASSINS IC50 - -
CHEMBL513326 IC50 > 1000000.0 nM -
CHEMBL467613 QUASSILACTOL IC50 = 576000.0 nM -
CHEMBL461393 QUASSILACTONE IC50 = 406000.0 nM -
CHEMBL58510 CHLOROQUINE PHOSPHATE IC50 - -