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Assay Detail

CHEMBL993817

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ADMET
Cytotoxicity against human KB cells by microplate method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type KB
Confidence 1 — Organism
Curated By Autocuration

Target

KB (CHEMBL398)
Type CELL-LINE
Organism Homo sapiens

Publication

Enhancement of the antiplasmodial activity of quassin by transformation into a gamma-lactone.
Lang'at-Thoruwa C, Kirby GC, Phillipson JD, Warhurst DC, Watt RA, Wright CW.
J Nat Prod (2003) 66 : 1486 -1489
PubMed 14640524 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.00 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL58510 CHLOROQUINE PHOSPHATE 4.0 1 6.22
CHEMBL501691 1 5.75
CHEMBL501777 NEOQUASSIN ETHER 1 5.01
CHEMBL461393 QUASSILACTONE 1 4.64
CHEMBL467613 QUASSILACTOL 1 4.19
CHEMBL467612 HYDROXYNEOQUASSINS 1 4.17
CHEMBL517016 QUASSIN 1 -
CHEMBL517757 NEOQUASSIN 1 -
CHEMBL468660 ANHYDROQUASSIN 1 -
CHEMBL513326 1 -
CHEMBL513000 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL58510 CHLOROQUINE PHOSPHATE IC50 = 600.0 nM 6.22
CHEMBL501691 IC50 = 1800.0 nM 5.75
CHEMBL501777 NEOQUASSIN ETHER IC50 = 9700.0 nM 5.01
CHEMBL461393 QUASSILACTONE IC50 = 23000.0 nM 4.64
CHEMBL467613 QUASSILACTOL IC50 = 65000.0 nM 4.19
CHEMBL467612 HYDROXYNEOQUASSINS IC50 = 68000.0 nM 4.17
CHEMBL517016 QUASSIN IC50 = 911000.0 nM -
CHEMBL517757 NEOQUASSIN IC50 = 473000.0 nM -
CHEMBL468660 ANHYDROQUASSIN IC50 = 809000.0 nM -
CHEMBL513326 IC50 = 930000.0 nM -
CHEMBL513000 IC50 - -