Assay Detail
Binding
CHEMBL993937
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Inhibition of rat recombinant nNOS expressed in Escherichia coli by hemoglobin capture assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 6.52 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480419 | — | — | 1 | 7.85 |
| CHEMBL517995 | — | — | 1 | 7.62 |
| CHEMBL480418 | — | — | 1 | 7.57 |
| CHEMBL519772 | — | — | 1 | 7.30 |
| CHEMBL481815 | — | — | 1 | 7.07 |
| CHEMBL481032 | — | — | 1 | 7.06 |
| CHEMBL481465 | — | — | 1 | 7.01 |
| CHEMBL480840 | — | — | 1 | 7.00 |
| CHEMBL481033 | — | — | 1 | 7.00 |
| CHEMBL480254 | — | — | 1 | 6.98 |
| CHEMBL479667 | — | — | 1 | 6.96 |
| CHEMBL481413 | — | — | 1 | 6.89 |
| CHEMBL480247 | — | — | 1 | 6.87 |
| CHEMBL480256 | — | — | 1 | 6.84 |
| CHEMBL479666 | — | — | 1 | 6.80 |
| CHEMBL479469 | — | — | 1 | 6.80 |
| CHEMBL480255 | — | — | 1 | 6.71 |
| CHEMBL479280 | — | — | 1 | 6.69 |
| CHEMBL481816 | — | — | 1 | 6.49 |
| CHEMBL516764 | — | — | 1 | 6.41 |
| CHEMBL508014 | — | — | 1 | 6.41 |
| CHEMBL520099 | — | — | 1 | 6.26 |
| CHEMBL519789 | — | — | 1 | 5.93 |
| CHEMBL520772 | — | — | 1 | 5.92 |
| CHEMBL517221 | — | — | 1 | 5.90 |
| CHEMBL479268 | — | — | 1 | 5.87 |
| CHEMBL482205 | — | — | 1 | 5.64 |
| CHEMBL482003 | — | — | 1 | 5.62 |
| CHEMBL479269 | — | — | 1 | 5.56 |
| CHEMBL521254 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480419 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL517995 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL480418 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL519772 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL481815 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL481032 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL481465 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL480840 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL481033 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL480254 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL479667 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL481413 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL480247 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL480256 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL479469 | — | Ki | = | 159.0 | nM | 6.80 |
| CHEMBL479666 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL480255 | — | Ki | = | 197.0 | nM | 6.71 |
| CHEMBL479280 | — | Ki | = | 206.0 | nM | 6.69 |
| CHEMBL481816 | — | Ki | = | 326.0 | nM | 6.49 |
| CHEMBL516764 | — | Ki | = | 393.0 | nM | 6.41 |
| CHEMBL508014 | — | Ki | = | 388.0 | nM | 6.41 |
| CHEMBL520099 | — | Ki | = | 551.0 | nM | 6.26 |
| CHEMBL519789 | — | Ki | = | 1180.0 | nM | 5.93 |
| CHEMBL520772 | — | Ki | = | 1210.0 | nM | 5.92 |
| CHEMBL517221 | — | Ki | = | 1260.0 | nM | 5.90 |
| CHEMBL479268 | — | Ki | = | 1360.0 | nM | 5.87 |
| CHEMBL482205 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL482003 | — | Ki | = | 2420.0 | nM | 5.62 |
| CHEMBL479269 | — | Ki | = | 2740.0 | nM | 5.56 |
| CHEMBL521254 | — | Ki | = | 3330.0 | nM | 5.48 |
| CHEMBL479270 | — | Ki | = | 3340.0 | nM | 5.48 |
| CHEMBL481420 | — | Ki | = | 18800.0 | nM | 4.73 |