Assay Detail
Binding
CHEMBL993950
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Inhibition of starfish oocytes CDK1/cyclin B
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Marthasterias glacialis |
| Cell Type | Oocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.10 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23327 | PURVALANOLA | — | 1 | 8.40 |
| CHEMBL482193 | — | — | 1 | 7.14 |
| CHEMBL480442 | — | — | 1 | 7.10 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 6.48 |
| CHEMBL482211 | — | — | 1 | 6.40 |
| CHEMBL521274 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23327 | PURVALANOLA | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL482193 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL480442 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL482211 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL521274 | — | IC50 | - | — | - |