Assay Detail
Binding
CHEMBL993952
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Inhibition of human recombinant CDK5/p25 expressed in Escherichia coli
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.91 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480442 | — | — | 1 | 7.22 |
| CHEMBL482193 | — | — | 1 | 7.16 |
| CHEMBL23327 | PURVALANOLA | — | 1 | 7.12 |
| CHEMBL521274 | — | — | 1 | 6.89 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 6.57 |
| CHEMBL482211 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480442 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL482193 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL23327 | PURVALANOLA | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL521274 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL482211 | — | IC50 | = | 320.0 | nM | 6.50 |