Assay Detail

CHEMBL994110

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Functional

Cytotoxicity against human OVCAR-3 cells after 72 hrs by XTT colorimetric assay

ChEMBL ↗

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Target

OVCAR-3 (CHEMBL614213) ↗

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OVCAR-3 (CHEMBL614213) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target OVCAR-3

CHEMBL614213

Anchored from Assay target.

Protein identity OVCAR-3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	OVCAR-3
Confidence	1 — Organism
Curated By	Autocuration

Target

OVCAR-3 (CHEMBL614213) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Antitumor compounds based on a natural product consensus pharmacophore.

Lagisetti C, Pourpak A, Jiang Q, Cui X, Goronga T, Morris SW, Webb TR.
J Med Chem (2008) 51 : 6220 -6224
PubMed 18788726 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.55	9.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1242745	PLADIENOLIDE B	—	1	9.40
CHEMBL493292	—	—	1	5.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1242745	PLADIENOLIDE B	IC50	=	0.4	nM	9.40
CHEMBL493292	—	IC50	=	1980.0	nM	5.70