Assay Detail
Functional
CHEMBL994207
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Cytotoxicity against human HT-29 cells after 4 hrs under strict hypoxic condition
39
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.19 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509303 | — | — | 1 | 5.82 |
| CHEMBL483193 | — | — | 1 | 5.82 |
| CHEMBL606799 | — | — | 1 | 5.64 |
| CHEMBL484379 | — | — | 1 | 5.62 |
| CHEMBL451204 | — | — | 2 | 5.62 |
| CHEMBL606853 | — | — | 1 | 5.60 |
| CHEMBL483374 | — | — | 1 | 5.58 |
| CHEMBL520968 | — | — | 1 | 5.54 |
| CHEMBL606856 | — | — | 1 | 5.52 |
| CHEMBL606908 | — | — | 1 | 5.47 |
| CHEMBL606803 | — | — | 1 | 5.46 |
| CHEMBL443731 | — | — | 1 | 5.44 |
| CHEMBL520001 | — | — | 1 | 5.39 |
| CHEMBL606800 | — | — | 1 | 5.39 |
| CHEMBL606905 | — | — | 1 | 5.38 |
| CHEMBL447340 | — | — | 1 | 5.32 |
| CHEMBL606801 | — | — | 1 | 5.31 |
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | 5.29 |
| CHEMBL606909 | — | — | 1 | 5.28 |
| CHEMBL484543 | — | — | 1 | 5.28 |
| CHEMBL606854 | — | — | 1 | 5.24 |
| CHEMBL606907 | — | — | 1 | 5.20 |
| CHEMBL394992 | — | — | 1 | 5.11 |
| CHEMBL483375 | — | — | 1 | 5.11 |
| CHEMBL484214 | — | — | 1 | 5.05 |
| CHEMBL484544 | — | — | 1 | 5.00 |
| CHEMBL484552 | — | — | 1 | 4.96 |
| CHEMBL606906 | — | — | 1 | 4.91 |
| CHEMBL519490 | — | — | 1 | 4.89 |
| CHEMBL483382 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509303 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL483193 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL606799 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL484379 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL451204 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL606853 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL483374 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL520968 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL606856 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL606908 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL606803 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL443731 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL520001 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL606800 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL606905 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL447340 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL606801 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL50882 | TIRAPAZAMINE | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL484543 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL606909 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL606854 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL606907 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL394992 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL483375 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL484214 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL484544 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL484552 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL606906 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL519490 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL451204 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL483382 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL606745 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL483195 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL606852 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL606855 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL483364 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL606802 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL484545 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL455533 | — | IC50 | = | 117000.0 | nM | - |