Assay Detail
Functional
CHEMBL994209
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Cytotoxicity against human SiHa cells after 4 hrs under strict hypoxic condition
39
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SiHa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.63 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL451204 | — | — | 2 | 6.52 |
| CHEMBL483193 | — | — | 1 | 6.52 |
| CHEMBL520001 | — | — | 1 | 6.16 |
| CHEMBL606799 | — | — | 1 | 6.16 |
| CHEMBL606853 | — | — | 1 | 6.16 |
| CHEMBL509303 | — | — | 1 | 6.10 |
| CHEMBL606905 | — | — | 1 | 6.05 |
| CHEMBL606801 | — | — | 1 | 6.00 |
| CHEMBL606908 | — | — | 1 | 6.00 |
| CHEMBL483374 | — | — | 1 | 5.96 |
| CHEMBL606800 | — | — | 1 | 5.96 |
| CHEMBL606909 | — | — | 1 | 5.92 |
| CHEMBL443731 | — | — | 1 | 5.89 |
| CHEMBL606854 | — | — | 1 | 5.89 |
| CHEMBL606803 | — | — | 1 | 5.85 |
| CHEMBL606856 | — | — | 1 | 5.80 |
| CHEMBL520968 | — | — | 1 | 5.77 |
| CHEMBL484379 | — | — | 1 | 5.75 |
| CHEMBL484543 | — | — | 1 | 5.72 |
| CHEMBL447340 | — | — | 1 | 5.62 |
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | 5.60 |
| CHEMBL606907 | — | — | 1 | 5.58 |
| CHEMBL483375 | — | — | 1 | 5.54 |
| CHEMBL394992 | — | — | 1 | 5.54 |
| CHEMBL483382 | — | — | 1 | 5.51 |
| CHEMBL606906 | — | — | 1 | 5.48 |
| CHEMBL484544 | — | — | 1 | 5.47 |
| CHEMBL483364 | — | — | 1 | 5.47 |
| CHEMBL484552 | — | — | 1 | 5.44 |
| CHEMBL484214 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL451204 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL483193 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL606799 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL606853 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL520001 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL509303 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL606905 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL606801 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL606908 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL483374 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL606800 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL606909 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL443731 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL606854 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL606803 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL606856 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL520968 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL484379 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL484543 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL447340 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL50882 | TIRAPAZAMINE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL606907 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL483375 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL394992 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL483382 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL606906 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL484544 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL483364 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL484552 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL451204 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL484214 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL483195 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL519490 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL606852 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL606745 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL606855 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL606802 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL455533 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL484545 | — | IC50 | = | 29000.0 | nM | 4.54 |