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Assay Detail

CHEMBL994216

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cells
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type NIH3T3
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

5-hydroxytryptamine receptor 2A (CHEMBL224)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation.
Runyon SP, Mosier PD, Roth BL, Glennon RA, Westkaemper RB.
J Med Chem (2008) 51 : 6808 -6828
PubMed 18847250 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 25 7.45 9.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL69700 1 9.54
CHEMBL51 KETANSERIN 3.0 1 9.40
CHEMBL6616 1 9.04
CHEMBL85882 1 8.89
CHEMBL468880 1 8.72
CHEMBL268890 1 8.60
CHEMBL83082 1 8.49
CHEMBL86760 1 8.15
CHEMBL83081 1 8.12
CHEMBL8334 1 8.00
CHEMBL47482 1 7.70
CHEMBL1744358 1 7.64
CHEMBL6607 BROLAMFETAMINE 2.0 1 7.39
CHEMBL484381 1 7.37
CHEMBL104088 1 7.22
CHEMBL483388 1 7.11
CHEMBL484380 1 6.97
CHEMBL501072 1 6.70
CHEMBL444761 1 6.58
CHEMBL8389 1 5.92
CHEMBL476516 1 5.75
CHEMBL10780 1 5.34
CHEMBL8642 1 5.28
CHEMBL610 PHENETHYLAMINE 1 4.78
CHEMBL8352 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL69700 Ki = 0.29 nM 9.54
CHEMBL51 KETANSERIN Ki = 0.4 nM 9.40
CHEMBL6616 Ki = 0.92 nM 9.04
CHEMBL85882 Ki = 1.3 nM 8.89
CHEMBL468880 Ki = 1.9 nM 8.72
CHEMBL268890 Ki = 2.5 nM 8.60
CHEMBL83082 Ki = 3.2 nM 8.49
CHEMBL86760 Ki = 7.0 nM 8.15
CHEMBL83081 Ki = 7.5 nM 8.12
CHEMBL8334 Ki = 10.0 nM 8.00
CHEMBL47482 Ki = 20.0 nM 7.70
CHEMBL1744358 Ki = 23.0 nM 7.64
CHEMBL6607 BROLAMFETAMINE Ki = 41.0 nM 7.39
CHEMBL484381 Ki = 43.0 nM 7.37
CHEMBL104088 Ki = 60.0 nM 7.22
CHEMBL483388 Ki = 78.0 nM 7.11
CHEMBL484380 Ki = 107.0 nM 6.97
CHEMBL501072 Ki = 200.0 nM 6.70
CHEMBL444761 Ki = 260.0 nM 6.58
CHEMBL8389 Ki = 1200.0 nM 5.92
CHEMBL476516 Ki = 1770.0 nM 5.75
CHEMBL10780 Ki = 4610.0 nM 5.34
CHEMBL8642 Ki = 5200.0 nM 5.28
CHEMBL610 PHENETHYLAMINE Ki = 16800.0 nM 4.78
CHEMBL8352 Ki > 50000.0 nM -