Assay Detail
Binding
CHEMBL994217
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ketanserein from 5HT2A receptor F340L mutant expressed in NIH3T3 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NIH3T3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.39 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 9.64 |
| CHEMBL85882 | — | — | 1 | 8.74 |
| CHEMBL444761 | — | — | 1 | 8.46 |
| CHEMBL47482 | — | — | 1 | 7.24 |
| CHEMBL10780 | — | — | 1 | 5.38 |
| CHEMBL6616 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51 | KETANSERIN | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL85882 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL444761 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL47482 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL10780 | — | Ki | = | 4140.0 | nM | 5.38 |
| CHEMBL6616 | — | Ki | = | 13700.0 | nM | 4.86 |