Assay Detail
Functional
CHEMBL994438
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Agonist activity against human CCK1 receptor
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of imidazole carboxamides as potent and selective CCK1R agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 45 | 8.29 | 10.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL498942 | — | — | 1 | 10.32 |
| CHEMBL510690 | — | — | 1 | 10.28 |
| CHEMBL504861 | — | — | 1 | 10.25 |
| CHEMBL509519 | — | — | 1 | 10.11 |
| CHEMBL448221 | — | — | 1 | 10.11 |
| CHEMBL505225 | — | — | 1 | 10.03 |
| CHEMBL505727 | — | — | 1 | 10.03 |
| CHEMBL514953 | — | — | 1 | 9.92 |
| CHEMBL474067 | — | — | 1 | 9.89 |
| CHEMBL451644 | — | — | 1 | 9.85 |
| CHEMBL473865 | — | — | 1 | 9.60 |
| CHEMBL475679 | — | — | 1 | 9.59 |
| CHEMBL455742 | — | — | 1 | 9.40 |
| CHEMBL515887 | — | — | 1 | 9.28 |
| CHEMBL453083 | — | — | 1 | 9.14 |
| CHEMBL478398 | — | — | 1 | 9.00 |
| CHEMBL473663 | — | — | 1 | 8.96 |
| CHEMBL479256 | — | — | 1 | 8.96 |
| CHEMBL473664 | — | — | 1 | 8.72 |
| CHEMBL476530 | — | — | 1 | 8.54 |
| CHEMBL473457 | — | — | 1 | 8.36 |
| CHEMBL476531 | — | — | 1 | 8.26 |
| CHEMBL516355 | — | — | 1 | 8.20 |
| CHEMBL515616 | — | — | 1 | 8.18 |
| CHEMBL476520 | — | — | 1 | 8.13 |
| CHEMBL515161 | — | — | 1 | 8.08 |
| CHEMBL477996 | — | — | 1 | 8.04 |
| CHEMBL478630 | — | — | 1 | 8.03 |
| CHEMBL479046 | — | — | 1 | 8.02 |
| CHEMBL516113 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL498942 | — | EC50 | = | 0.048 | nM | 10.32 |
| CHEMBL510690 | — | EC50 | = | 0.053 | nM | 10.28 |
| CHEMBL504861 | — | EC50 | = | 0.056 | nM | 10.25 |
| CHEMBL509519 | — | EC50 | = | 0.077 | nM | 10.11 |
| CHEMBL448221 | — | EC50 | = | 0.078 | nM | 10.11 |
| CHEMBL505225 | — | EC50 | = | 0.093 | nM | 10.03 |
| CHEMBL505727 | — | EC50 | = | 0.094 | nM | 10.03 |
| CHEMBL514953 | — | EC50 | = | 0.12 | nM | 9.92 |
| CHEMBL474067 | — | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL451644 | — | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL473865 | — | EC50 | = | 0.25 | nM | 9.60 |
| CHEMBL475679 | — | EC50 | = | 0.26 | nM | 9.59 |
| CHEMBL455742 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL515887 | — | EC50 | = | 0.53 | nM | 9.28 |
| CHEMBL453083 | — | EC50 | = | 0.73 | nM | 9.14 |
| CHEMBL478398 | — | EC50 | = | 0.99 | nM | 9.00 |
| CHEMBL473663 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL479256 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL473664 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL476530 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL473457 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL476531 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL516355 | — | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL515616 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL476520 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL515161 | — | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL477996 | — | EC50 | = | 9.1 | nM | 8.04 |
| CHEMBL478630 | — | EC50 | = | 9.3 | nM | 8.03 |
| CHEMBL479046 | — | EC50 | = | 9.6 | nM | 8.02 |
| CHEMBL516113 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL476095 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL476739 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL478397 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL476747 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL478604 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL476297 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL515160 | — | EC50 | = | 105.0 | nM | 6.98 |
| CHEMBL514716 | — | EC50 | = | 106.0 | nM | 6.97 |
| CHEMBL476725 | — | EC50 | = | 175.0 | nM | 6.76 |
| CHEMBL479063 | — | EC50 | = | 308.0 | nM | 6.51 |
| CHEMBL476519 | — | EC50 | = | 471.0 | nM | 6.33 |
| CHEMBL479030 | — | EC50 | = | 962.0 | nM | 6.02 |
| CHEMBL448597 | — | EC50 | = | 1349.0 | nM | 5.87 |
| CHEMBL504024 | — | EC50 | = | 3152.0 | nM | 5.50 |
| CHEMBL477784 | — | EC50 | = | 5371.0 | nM | 5.27 |