Assay Detail
Binding
CHEMBL994471
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Inhibition of HIV1 reverse transcriptase RNA-dependent DNA polymerase activity assessed as incorporation of radioactive dTTP into poly(rA)/oligo(DT)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.69 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477192 | — | — | 1 | 8.52 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.40 |
| CHEMBL234401 | — | — | 1 | 8.30 |
| CHEMBL450764 | — | — | 1 | 7.77 |
| CHEMBL506852 | — | — | 1 | 7.34 |
| CHEMBL443883 | — | — | 1 | 7.00 |
| CHEMBL479069 | — | — | 1 | 7.00 |
| CHEMBL518737 | — | — | 1 | 7.00 |
| CHEMBL515189 | — | — | 1 | 6.85 |
| CHEMBL234400 | — | — | 1 | 6.82 |
| CHEMBL514396 | — | — | 1 | 6.80 |
| CHEMBL444417 | — | — | 1 | 6.80 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.75 |
| CHEMBL478236 | — | — | 1 | 6.70 |
| CHEMBL443879 | — | — | 1 | 6.55 |
| CHEMBL393003 | — | — | 1 | 6.16 |
| CHEMBL447646 | — | — | 1 | 5.89 |
| CHEMBL507975 | — | — | 1 | 4.52 |
| CHEMBL477602 | — | — | 1 | 4.42 |
| CHEMBL477603 | — | — | 1 | 4.11 |
| CHEMBL518738 | — | — | 1 | - |
| CHEMBL479068 | — | — | 1 | - |
| CHEMBL478235 | — | — | 1 | - |
| CHEMBL516423 | — | — | 1 | - |
| CHEMBL514527 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477192 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL234401 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL450764 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL506852 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL443883 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL479069 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL518737 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL515189 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL234400 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL514396 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL444417 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL478236 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL443879 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL393003 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL447646 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL507975 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL477602 | — | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL477603 | — | IC50 | = | 76920.0 | nM | 4.11 |
| CHEMBL518738 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL479068 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL478235 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL516423 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL514527 | — | IC50 | > | 100000.0 | nM | - |