Assay Detail
Toxicity
CHEMBL994719
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Toxicity in iv dosed gerbils plasma assessed as inhibition of GR-73632-induced foot tapping after 24 hrs
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Gerbillinae |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.22 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447955 | SERLOPITANT | 3.0 | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447955 | SERLOPITANT | IC50 | = | 6.0 | nM | 8.22 |