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Assay Detail

CHEMBL995053

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of NOS in Sprague-Dawley rat brain by oxyhaemoglobin assay
16
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Fluorescent polycyclic ligands for nitric oxide synthase (NOS) inhibition.
Joubert J, van Dyk S, Malan SF.
Bioorg Med Chem (2008) 16 : 8952 -8958
PubMed 18805011 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.44 6.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL247378 7-NITROINDAZOLE 2 6.96
CHEMBL478025 2 6.54
CHEMBL522596 2 6.46
CHEMBL478228 2 5.60
CHEMBL502057 2 5.01
CHEMBL225304 PIMAGEDINE 2.0 2 4.71
CHEMBL490813 1 -
CHEMBL515178 1 -
CHEMBL510162 1 -
CHEMBL479073 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL247378 7-NITROINDAZOLE IC50 = 111.0 nM 6.96
CHEMBL478025 IC50 = 291.0 nM 6.54
CHEMBL522596 IC50 = 350.0 nM 6.46
CHEMBL478228 IC50 = 2530.0 nM 5.60
CHEMBL502057 IC50 = 9650.0 nM 5.01
CHEMBL247378 7-NITROINDAZOLE IC50 = 10964.78 nM 4.96
CHEMBL225304 PIMAGEDINE IC50 = 19410.0 nM 4.71
CHEMBL478025 IC50 = 30199.52 nM 4.52
CHEMBL522596 IC50 = 60255.96 nM 4.22
CHEMBL490813 IC50 = 1174897.55 nM -
CHEMBL502057 IC50 = 524807.46 nM -
CHEMBL225304 PIMAGEDINE IC50 = 1905460.72 nM -
CHEMBL515178 IC50 = 181970.09 nM -
CHEMBL510162 IC50 = 131825.67 nM -
CHEMBL478228 IC50 = 301995.17 nM -
CHEMBL479073 IC50 = 2951209.23 nM -