Assay Detail
Functional
CHEMBL995061
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Antiproliferative activity against human BxPC3 cells by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BXPC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.39 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL520025 | — | — | 1 | 7.60 |
| CHEMBL103045 | — | — | 1 | 7.58 |
| CHEMBL485574 | — | — | 1 | 7.50 |
| CHEMBL485237 | — | — | 1 | 7.41 |
| CHEMBL521013 | — | — | 1 | 7.40 |
| CHEMBL485211 | — | — | 1 | 7.40 |
| CHEMBL489661 | — | — | 1 | 7.39 |
| CHEMBL521320 | — | — | 1 | 7.38 |
| CHEMBL485238 | — | — | 1 | 7.37 |
| CHEMBL519206 | — | — | 1 | 7.36 |
| CHEMBL520142 | — | — | 1 | 7.32 |
| CHEMBL489058 | — | — | 1 | 7.32 |
| CHEMBL521502 | — | — | 1 | 7.29 |
| CHEMBL484368 | — | — | 1 | 7.14 |
| CHEMBL483398 | — | — | 1 | - |
| CHEMBL485377 | — | — | 1 | - |
| CHEMBL485615 | — | — | 1 | - |
| CHEMBL524111 | — | — | 1 | - |
| CHEMBL450271 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL520025 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL103045 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL485574 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL485237 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL521013 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL485211 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL489661 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL521320 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL485238 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL519206 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL520142 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL489058 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL521502 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL484368 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL483398 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL485377 | — | IC50 | - | — | - | |
| CHEMBL485615 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL524111 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL450271 | — | IC50 | > | 1000.0 | nM | - |