Assay Detail
Binding
CHEMBL995077
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Inhibition of Cryptosporidium hominis dihydrofolate reductase expressed in Escherichia coli by spectrophotometry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cryptosporidium hominis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.10 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL459177 | — | — | 1 | 8.96 |
| CHEMBL520358 | — | — | 1 | 8.74 |
| CHEMBL457725 | — | — | 1 | 8.68 |
| CHEMBL485569 | — | — | 1 | 8.68 |
| CHEMBL458817 | — | — | 1 | 8.13 |
| CHEMBL457726 | — | — | 1 | 8.00 |
| CHEMBL458829 | — | — | 1 | 7.80 |
| CHEMBL457905 | — | — | 1 | 7.72 |
| CHEMBL459178 | — | — | 1 | 7.52 |
| CHEMBL457906 | — | — | 1 | 7.44 |
| CHEMBL223301 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL459177 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL520358 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL457725 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL485569 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL458817 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL457726 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL458829 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL457905 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL459178 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL457906 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL223301 | — | IC50 | = | 38.0 | nM | 7.42 |