Assay Detail
Binding
CHEMBL995078
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Inhibition of human dihydrofolate reductase by spectrophotometry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.68 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL457725 | — | — | 1 | 5.90 |
| CHEMBL485569 | — | — | 1 | 5.87 |
| CHEMBL459177 | — | — | 1 | 5.87 |
| CHEMBL223301 | — | — | 1 | 5.86 |
| CHEMBL459178 | — | — | 1 | 5.86 |
| CHEMBL457905 | — | — | 1 | 5.85 |
| CHEMBL520358 | — | — | 1 | 5.77 |
| CHEMBL457906 | — | — | 1 | 5.56 |
| CHEMBL458817 | — | — | 1 | 5.47 |
| CHEMBL458829 | — | — | 1 | 5.38 |
| CHEMBL457726 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL457725 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL485569 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL459177 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL223301 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL459178 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL457905 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL520358 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL457906 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL458817 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL458829 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL457726 | — | IC50 | = | 7200.0 | nM | 5.14 |