Assay Detail
Binding
CHEMBL995087
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human D2long receptor expressed in CHO cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.92 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484358 | — | — | 1 | 7.40 |
| CHEMBL491466 | — | — | 1 | 6.68 |
| CHEMBL483593 | — | — | 1 | 6.66 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.35 |
| CHEMBL484202 | — | — | 1 | 6.21 |
| CHEMBL485384 | — | — | 1 | 6.16 |
| CHEMBL484203 | — | — | 1 | 5.39 |
| CHEMBL485227 | — | — | 1 | 5.33 |
| CHEMBL484357 | — | — | 1 | 5.26 |
| CHEMBL484204 | — | — | 1 | 5.01 |
| CHEMBL444128 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484358 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL491466 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL483593 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL59 | DOPAMINE | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL484202 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL485384 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL484203 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL485227 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL484357 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL484204 | — | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL444128 | — | Ki | = | 21000.0 | nM | 4.68 |