Assay Detail
Binding
CHEMBL995088
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Displacement of [3H]spiperone from human D2short receptor expressed in CHO cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.12 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484358 | — | — | 1 | 7.37 |
| CHEMBL484202 | — | — | 1 | 6.77 |
| CHEMBL491466 | — | — | 1 | 6.75 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.44 |
| CHEMBL483593 | — | — | 1 | 6.44 |
| CHEMBL485384 | — | — | 1 | 6.17 |
| CHEMBL484203 | — | — | 1 | 5.68 |
| CHEMBL484357 | — | — | 1 | 5.33 |
| CHEMBL485227 | — | — | 1 | 5.20 |
| CHEMBL484204 | — | — | 1 | 5.06 |
| CHEMBL444128 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484358 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL484202 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL491466 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL59 | DOPAMINE | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL483593 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL485384 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL484203 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL484357 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL485227 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL484204 | — | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL444128 | — | Ki | > | 100000.0 | nM | - |