Assay Detail
Binding
CHEMBL995090
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Displacement of [3H]spiperone from human D4 receptor expressed in CHO cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.54 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484358 | — | — | 1 | 8.37 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 8.21 |
| CHEMBL483593 | — | — | 1 | 7.16 |
| CHEMBL484203 | — | — | 1 | 7.00 |
| CHEMBL484202 | — | — | 1 | 6.72 |
| CHEMBL485227 | — | — | 1 | 6.17 |
| CHEMBL491466 | — | — | 1 | 5.96 |
| CHEMBL484204 | — | — | 1 | 5.85 |
| CHEMBL485384 | — | — | 1 | 5.75 |
| CHEMBL484357 | — | — | 1 | 5.51 |
| CHEMBL444128 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484358 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL59 | DOPAMINE | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL483593 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL484203 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL484202 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL485227 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL491466 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL484204 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL485384 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL484357 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL444128 | — | Ki | = | 6100.0 | nM | 5.21 |