Assay Detail
Binding
CHEMBL995091
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Displacement of [3H]SCH23390 from D1 receptor in pig striatal membrane
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.28 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491466 | — | — | 1 | 5.77 |
| CHEMBL484358 | — | — | 1 | 5.54 |
| CHEMBL483593 | — | — | 1 | 5.42 |
| CHEMBL485227 | — | — | 1 | 5.34 |
| CHEMBL485384 | — | — | 1 | 5.24 |
| CHEMBL484204 | — | — | 1 | 5.17 |
| CHEMBL444128 | — | — | 1 | 5.14 |
| CHEMBL484202 | — | — | 1 | 5.02 |
| CHEMBL484357 | — | — | 1 | 4.89 |
| CHEMBL484203 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491466 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL484358 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL483593 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL485227 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL485384 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL484204 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL444128 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL484202 | — | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL484357 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL484203 | — | Ki | > | 100000.0 | nM | - |