Assay Detail
Functional
CHEMBL995104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP release
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.46 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484358 | — | — | 1 | 8.68 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 8.54 |
| CHEMBL484202 | — | — | 1 | 8.51 |
| CHEMBL162762 | — | — | 1 | 8.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484358 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL240773 | QUINPIROLE | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL484202 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL162762 | — | EC50 | = | 7.7 | nM | 8.11 |