Assay Detail
Binding
CHEMBL995173
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Inhibition of human trypsin by Dixon-plot method
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Orally active factor Xa inhibitors: investigation of a novel series of 3-amidinophenylsulfonamide derivatives using an amidoxime prodrug strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.75 | 6.11 |
| IC50 | 2 | 5.39 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455914 | — | — | 1 | 6.11 |
| CHEMBL463581 | — | — | 1 | 6.10 |
| CHEMBL463179 | — | — | 1 | 5.93 |
| CHEMBL513605 | — | — | 1 | 5.77 |
| CHEMBL457391 | — | — | 1 | 5.40 |
| CHEMBL463385 | — | — | 1 | 5.21 |
| CHEMBL513433 | — | — | 1 | 5.01 |
| CHEMBL457392 | — | — | 1 | - |
| CHEMBL456763 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455914 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL463581 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL463179 | — | Ki | = | 1170.0 | nM | 5.93 |
| CHEMBL513605 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL457391 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL463385 | — | Ki | = | 6170.0 | nM | 5.21 |
| CHEMBL513433 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL457392 | — | Ki | - | — | - | |
| CHEMBL456763 | — | Ki | - | — | - |