Assay Detail
Binding
CHEMBL995199
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Inhibition of dopamine uptake at human DAT expressed in HEK cells
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.40 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497679 | — | — | 1 | 5.85 |
| CHEMBL295467 | NISOXETINE | 2.0 | 1 | 5.62 |
| CHEMBL641 | ATOMOXETINE | 4.0 | 1 | 5.52 |
| CHEMBL526306 | — | — | 1 | 5.40 |
| CHEMBL497492 | — | — | 1 | 5.40 |
| CHEMBL526669 | — | — | 1 | 5.39 |
| CHEMBL498495 | — | — | 1 | 5.38 |
| CHEMBL455447 | — | — | 1 | 5.28 |
| CHEMBL524271 | — | — | 1 | 5.24 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 5.22 |
| CHEMBL523574 | — | — | 1 | 5.12 |
| CHEMBL497845 | — | — | 1 | - |
| CHEMBL525375 | — | — | 1 | - |
| CHEMBL498680 | — | — | 1 | - |
| CHEMBL526270 | — | — | 1 | - |
| CHEMBL448375 | — | — | 1 | - |
| CHEMBL497846 | — | — | 1 | - |
| CHEMBL505902 | — | — | 1 | - |
| CHEMBL497666 | — | — | 1 | - |
| CHEMBL497664 | — | — | 1 | - |
| CHEMBL497665 | — | — | 1 | - |
| CHEMBL497512 | — | — | 1 | - |
| CHEMBL524798 | — | — | 1 | - |
| CHEMBL497479 | — | — | 1 | - |
| CHEMBL451105 | — | — | 1 | - |
| CHEMBL445082 | — | — | 1 | - |
| CHEMBL498509 | — | — | 1 | - |
| CHEMBL498510 | — | — | 1 | - |
| CHEMBL505433 | — | — | 1 | - |
| CHEMBL526825 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497679 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL295467 | NISOXETINE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL641 | ATOMOXETINE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL526306 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL497492 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL526669 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL498495 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL455447 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL524271 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL41 | FLUOXETINE | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL523574 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL526270 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL497493 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL498680 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL525375 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL497845 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL505439 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL496284 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL497680 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL498686 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL526670 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL498687 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL522065 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL524624 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL496285 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL444742 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL448375 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL497846 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL505902 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL497666 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL497664 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL497665 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL497512 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL524798 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL497479 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL451105 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL445082 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL498509 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL498510 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL505433 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL526825 | — | IC50 | > | 10000.0 | nM | - |