Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL995264

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HIV2 RNase H by FRET assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 2
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

HIV-1 ribonuclease H inhibitory phenolic glycosides from Eugenia hyemalis.
Bokesch HR, Wamiru A, Le Grice SF, Beutler JA, McKee TC, McMahon JB.
J Nat Prod (2008) 71 : 1634 -1636
PubMed 18763827 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.84 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL341631 1 7.00
CHEMBL447974 1 6.55
CHEMBL501741 1 6.55
CHEMBL509744 HYEMALOSIDE A 1 6.24
CHEMBL506679 HYEMALOSIDE C 1 6.08
CHEMBL498793 HYEMALOSIDE B 1 5.48
CHEMBL445952 1 5.47
CHEMBL503183 1 5.29
CHEMBL507268 1 5.04
CHEMBL82242 QUERCITRIN 1 4.67
CHEMBL498794 1 -
CHEMBL526112 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL341631 IC50 = 100.0 nM 7.00
CHEMBL447974 IC50 = 280.0 nM 6.55
CHEMBL501741 IC50 = 280.0 nM 6.55
CHEMBL509744 HYEMALOSIDE A IC50 = 580.0 nM 6.24
CHEMBL506679 HYEMALOSIDE C IC50 = 840.0 nM 6.08
CHEMBL498793 HYEMALOSIDE B IC50 = 3320.0 nM 5.48
CHEMBL445952 IC50 = 3380.0 nM 5.47
CHEMBL503183 IC50 = 5190.0 nM 5.29
CHEMBL507268 IC50 = 9120.0 nM 5.04
CHEMBL82242 QUERCITRIN IC50 = 21270.0 nM 4.67
CHEMBL498794 IC50 > 23500.0 nM -
CHEMBL526112 IC50 > 23500.0 nM -