Assay Detail
Functional
CHEMBL995289
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Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.03 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.05 |
| CHEMBL1236460 | THIOSTREPTON | — | 1 | 6.66 |
| CHEMBL1440 | TETRACYCLINE | 4.0 | 1 | 6.44 |
| CHEMBL1200699 | DOXYCYCLINE | 4.0 | 1 | 6.22 |
| CHEMBL529 | AZITHROMYCIN | 4.0 | 1 | 5.40 |
| CHEMBL532 | ERYTHROMYCIN | 4.0 | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 89.6 | nM | 7.05 |
| CHEMBL1236460 | THIOSTREPTON | IC50 | = | 217.4 | nM | 6.66 |
| CHEMBL1440 | TETRACYCLINE | IC50 | = | 364.7 | nM | 6.44 |
| CHEMBL1200699 | DOXYCYCLINE | IC50 | = | 603.1 | nM | 6.22 |
| CHEMBL529 | AZITHROMYCIN | IC50 | = | 3971.7 | nM | 5.40 |
| CHEMBL532 | ERYTHROMYCIN | IC50 | = | 39500.0 | nM | 4.40 |