Assay Detail
Functional
CHEMBL995355
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Antiviral activity against Camelpox virus CML14 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Camelpox virus |
| Cell Type | HEL 299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 5.33 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL520710 | — | — | 1 | 7.70 |
| CHEMBL112159 | — | — | 1 | 7.00 |
| CHEMBL286534 | — | — | 1 | 6.30 |
| CHEMBL261240 | — | — | 1 | 6.22 |
| CHEMBL261691 | — | — | 1 | 5.77 |
| CHEMBL442946 | — | — | 1 | 5.72 |
| CHEMBL483890 | — | — | 1 | 5.70 |
| CHEMBL1162464 | — | — | 1 | 5.52 |
| CHEMBL223737 | GS-438 | -1.0 | 1 | 5.26 |
| CHEMBL1162466 | — | — | 1 | 5.23 |
| CHEMBL1162465 | — | — | 1 | 5.19 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 5.18 |
| CHEMBL1162463 | — | — | 1 | 5.12 |
| CHEMBL392630 | CYCLIC CIDOFOVIR | — | 1 | 5.06 |
| CHEMBL293466 | — | — | 1 | 5.03 |
| CHEMBL219724 | — | — | 1 | 4.92 |
| CHEMBL485447 | — | — | 1 | 4.61 |
| CHEMBL485101 | — | — | 1 | 4.54 |
| CHEMBL521338 | — | — | 1 | 4.35 |
| CHEMBL483263 | — | — | 1 | 4.34 |
| CHEMBL483264 | — | — | 1 | 4.25 |
| CHEMBL485100 | — | — | 1 | 4.14 |
| CHEMBL298845 | — | — | 1 | - |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | - |
| CHEMBL483891 | — | — | 1 | - |
| CHEMBL62984 | — | — | 1 | - |
| CHEMBL61733 | PMEDAP | — | 1 | - |
| CHEMBL2021514 | — | — | 1 | - |
| CHEMBL2021513 | — | — | 1 | - |
| CHEMBL147814 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL520710 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL112159 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL286534 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL261240 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL261691 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL442946 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL483890 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1162464 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL223737 | GS-438 | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1162466 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1162465 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL1162463 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL392630 | CYCLIC CIDOFOVIR | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL293466 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL219724 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL485447 | — | EC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL485101 | — | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL521338 | — | EC50 | = | 44300.0 | nM | 4.35 |
| CHEMBL483263 | — | EC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL483264 | — | EC50 | = | 55700.0 | nM | 4.25 |
| CHEMBL485100 | — | EC50 | = | 71600.0 | nM | 4.14 |
| CHEMBL484895 | — | EC50 | = | 112000.0 | nM | - |
| CHEMBL519814 | — | EC50 | > | 115000.0 | nM | - |
| CHEMBL483278 | — | EC50 | > | 118000.0 | nM | - |
| CHEMBL485517 | — | EC50 | > | 124000.0 | nM | - |
| CHEMBL484691 | — | EC50 | > | 126000.0 | nM | - |
| CHEMBL491068 | — | EC50 | > | 127000.0 | nM | - |
| CHEMBL519211 | — | EC50 | > | 134000.0 | nM | - |
| CHEMBL520516 | — | EC50 | > | 139000.0 | nM | - |
| CHEMBL147814 | — | EC50 | > | 156000.0 | nM | - |
| CHEMBL2021513 | — | EC50 | > | 164000.0 | nM | - |
| CHEMBL2021514 | — | EC50 | > | 164000.0 | nM | - |
| CHEMBL61733 | PMEDAP | EC50 | > | 173000.0 | nM | - |
| CHEMBL62984 | — | EC50 | > | 174000.0 | nM | - |
| CHEMBL483891 | — | EC50 | > | 176000.0 | nM | - |
| CHEMBL484 | ADEFOVIR | EC50 | > | 183000.0 | nM | - |
| CHEMBL298845 | — | EC50 | > | 189000.0 | nM | - |