Assay Detail
Binding
CHEMBL995444
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Inhibition of EGFP-fused human SPHK1 expressed in CHO cells using D-erythro-sphingosine as substrate by Michaelis-Menten plot
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.58 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495816 | — | — | 1 | 6.00 |
| CHEMBL495798 | — | — | 1 | 5.52 |
| CHEMBL322333 | DIMETHYLSPINGOSINE | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495816 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL495798 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL322333 | DIMETHYLSPINGOSINE | Ki | = | 6000.0 | nM | 5.22 |