Assay Detail
Binding
CHEMBL995857
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ditolylguanidine from sigma 2 opioid receptor in rat brain cerebellum
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebellum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Nitrile analogs of meperidine as high affinity and selective sigma-1 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.56 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502461 | — | — | 1 | 7.34 |
| CHEMBL486190 | — | — | 1 | 7.20 |
| CHEMBL495759 | — | — | 1 | 6.93 |
| CHEMBL75228 | 1-PHENETHYLPIPERIDINE | — | 1 | 6.86 |
| CHEMBL473112 | — | — | 1 | 6.84 |
| CHEMBL143950 | — | — | 1 | 6.77 |
| CHEMBL495548 | — | — | 1 | 6.32 |
| CHEMBL495549 | — | — | 1 | 6.18 |
| CHEMBL495955 | — | — | 1 | 6.18 |
| CHEMBL495760 | — | — | 1 | 5.88 |
| CHEMBL495954 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502461 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL486190 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL495759 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL75228 | 1-PHENETHYLPIPERIDINE | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL473112 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL143950 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL495548 | — | Ki | = | 482.0 | nM | 6.32 |
| CHEMBL495549 | — | Ki | = | 657.0 | nM | 6.18 |
| CHEMBL495955 | — | Ki | = | 662.0 | nM | 6.18 |
| CHEMBL495760 | — | Ki | = | 1310.0 | nM | 5.88 |
| CHEMBL495954 | — | Ki | = | 2142.0 | nM | 5.67 |