Assay Detail
Functional
CHEMBL995920
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Antiproliferative activity against human NCI-H661 cells after 48 hrs by XTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H661 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.30 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL489715 | — | — | 1 | 7.35 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.00 |
| CHEMBL424753 | — | — | 1 | 6.52 |
| CHEMBL491556 | — | — | 1 | 6.00 |
| CHEMBL523609 | — | — | 1 | 5.52 |
| CHEMBL489716 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL489715 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL424753 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL491556 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL523609 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL489716 | — | IC50 | = | 4000.0 | nM | 5.40 |