Assay Detail
Binding
CHEMBL995930
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human recombinant glucagon receptor expressed in BHK cells by membrane filter assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BHK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.26 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL493019 | — | — | 1 | 7.60 |
| CHEMBL448561 | — | — | 1 | 7.47 |
| CHEMBL491920 | — | — | 1 | 7.42 |
| CHEMBL451288 | — | — | 1 | 7.32 |
| CHEMBL501628 | — | — | 1 | 7.29 |
| CHEMBL471580 | — | — | 1 | 7.28 |
| CHEMBL519776 | — | — | 1 | 7.28 |
| CHEMBL492813 | — | — | 1 | 7.27 |
| CHEMBL455323 | — | — | 1 | 7.23 |
| CHEMBL492605 | — | — | 1 | 7.19 |
| CHEMBL523847 | — | — | 1 | 7.03 |
| CHEMBL470729 | — | — | 1 | 7.03 |
| CHEMBL446821 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL493019 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL448561 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL491920 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL451288 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL501628 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL471580 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL519776 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL492813 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL455323 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL492605 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL523847 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL470729 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL446821 | — | IC50 | = | 96.0 | nM | 7.02 |