Assay Detail

CHEMBL996022

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antimalarial activity against Plasmodium falciparum FCK2 by [3H]hypoxanthine uptake

ChEMBL ↗

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Target

Plasmodium falciparum (CHEMBL364) ↗

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Primary target Plasmodium falciparum

CHEMBL364

Anchored from Assay target.

Protein identity Plasmodium falciparum

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Plasmodium falciparum
Confidence	1 — Organism
Curated By	Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗

Type	ORGANISM
Organism	Plasmodium falciparum

Publication

15-deoxyspergualin primarily targets the trafficking of apicoplast proteins in Plasmodium falciparum.

Ramya TN, Karmodiya K, Surolia A, Surolia N.
J Biol Chem (2007) 282 : 6388 -6397
PubMed 17194705 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.83	6.83

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL406117	GUSPERIMUS	3.0	1	6.83

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL406117	GUSPERIMUS	IC50	=	148.0	nM	6.83