Assay Detail
Binding
CHEMBL996067
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Selectivity for human muscarinic acetylcholine M3 receptor over human muscarinic acetylcholine M2 receptor
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptors; M2 & M3 (CHEMBL2095187) ↗| Type | SELECTIVITY GROUP |
| Organism | Homo sapiens |
Publication
Discovery of novel and long acting muscarinic acetylcholine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Selectivity ratio | 4 | - | - |
| Kd | 1 | 10.90 | 10.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL539887 | — | — | 1 | 10.90 |
| CHEMBL505452 | — | — | 1 | - |
| CHEMBL526009 | — | — | 1 | - |
| CHEMBL540359 | — | — | 1 | - |
| CHEMBL540396 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL539887 | — | Kd | = | 0.01259 | nM | 10.90 |
| CHEMBL505452 | — | Selectivity ratio | = | 10.0 | — | - |
| CHEMBL526009 | — | Selectivity ratio | = | 10.0 | — | - |
| CHEMBL540359 | — | Selectivity ratio | = | 10.0 | — | - |
| CHEMBL540396 | — | Selectivity ratio | = | 15.0 | — | - |