Assay Detail
Binding
CHEMBL996083
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Inhibition of human recombinant SHP2
31
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 11 (CHEMBL3864) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.32 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL501993 | — | — | 1 | 6.52 |
| CHEMBL526644 | — | — | 1 | 6.10 |
| CHEMBL502013 | — | — | 1 | 6.00 |
| CHEMBL502539 | — | — | 1 | 5.89 |
| CHEMBL502815 | — | — | 1 | 5.85 |
| CHEMBL525768 | — | — | 1 | 5.75 |
| CHEMBL525630 | — | — | 1 | 5.60 |
| CHEMBL502540 | — | — | 1 | 5.42 |
| CHEMBL525812 | — | — | 1 | 5.36 |
| CHEMBL526866 | — | — | 1 | 5.35 |
| CHEMBL499329 | — | — | 1 | 5.35 |
| CHEMBL502014 | — | — | 1 | 5.32 |
| CHEMBL527109 | — | — | 1 | 5.30 |
| CHEMBL500677 | — | — | 1 | 5.28 |
| CHEMBL502006 | — | — | 1 | 5.26 |
| CHEMBL499061 | — | — | 1 | 5.23 |
| CHEMBL526369 | — | — | 1 | 5.20 |
| CHEMBL525078 | — | — | 1 | 5.13 |
| CHEMBL498473 | — | — | 1 | 5.08 |
| CHEMBL326115 | — | — | 1 | 5.00 |
| CHEMBL498474 | — | — | 1 | 4.97 |
| CHEMBL446483 | — | — | 1 | 4.92 |
| CHEMBL497509 | — | — | 1 | 4.80 |
| CHEMBL497510 | — | — | 1 | 4.65 |
| CHEMBL526177 | — | — | 1 | 4.64 |
| CHEMBL502257 | — | — | 1 | 4.33 |
| CHEMBL498475 | — | — | 1 | - |
| CHEMBL498650 | — | — | 1 | - |
| CHEMBL521563 | — | — | 1 | - |
| CHEMBL498479 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL501993 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL526644 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL502013 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL502539 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL502815 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL525768 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL525630 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL502540 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL525812 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL526866 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL499329 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL502014 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL527109 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL500677 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL502006 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL499061 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL526369 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL525078 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL498473 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL326115 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL498474 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL446483 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL497509 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL497510 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL526177 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL502257 | — | IC50 | = | 46800.0 | nM | 4.33 |
| CHEMBL498475 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL498479 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL498650 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL521563 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL498479 | — | IC50 | > | 60000.0 | nM | - |