Assay Detail
Binding
CHEMBL996084
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Inhibition of human recombinant SHP1
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 6 (CHEMBL3166) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.55 | 5.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502539 | — | — | 1 | 5.15 |
| CHEMBL526369 | — | — | 1 | 4.97 |
| CHEMBL526644 | — | — | 1 | 4.81 |
| CHEMBL526866 | — | — | 1 | 4.80 |
| CHEMBL502006 | — | — | 1 | 4.80 |
| CHEMBL502815 | — | — | 1 | 4.75 |
| CHEMBL499061 | — | — | 1 | 4.74 |
| CHEMBL502013 | — | — | 1 | 4.74 |
| CHEMBL497510 | — | — | 1 | 4.71 |
| CHEMBL499329 | — | — | 1 | 4.56 |
| CHEMBL527109 | — | — | 1 | 4.49 |
| CHEMBL526177 | — | — | 1 | 4.49 |
| CHEMBL525812 | — | — | 1 | 4.39 |
| CHEMBL498473 | — | — | 1 | 4.37 |
| CHEMBL502540 | — | — | 1 | 4.37 |
| CHEMBL525078 | — | — | 1 | 4.22 |
| CHEMBL502257 | — | — | 1 | 4.17 |
| CHEMBL497509 | — | — | 1 | 4.14 |
| CHEMBL500677 | — | — | 1 | 4.13 |
| CHEMBL498474 | — | — | 1 | 4.13 |
| CHEMBL502014 | — | — | 1 | - |
| CHEMBL446483 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502539 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL526369 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL526644 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL526866 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL502006 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL502815 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL499061 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL502013 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL497510 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL499329 | — | IC50 | = | 27700.0 | nM | 4.56 |
| CHEMBL527109 | — | IC50 | = | 32600.0 | nM | 4.49 |
| CHEMBL526177 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL525812 | — | IC50 | = | 40900.0 | nM | 4.39 |
| CHEMBL498473 | — | IC50 | = | 43100.0 | nM | 4.37 |
| CHEMBL502540 | — | IC50 | = | 42500.0 | nM | 4.37 |
| CHEMBL525078 | — | IC50 | = | 60800.0 | nM | 4.22 |
| CHEMBL502257 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL497509 | — | IC50 | = | 72500.0 | nM | 4.14 |
| CHEMBL500677 | — | IC50 | = | 73400.0 | nM | 4.13 |
| CHEMBL498474 | — | IC50 | = | 74200.0 | nM | 4.13 |
| CHEMBL502014 | — | IC50 | = | 122800.0 | nM | - |
| CHEMBL446483 | — | IC50 | = | 103700.0 | nM | - |