Assay Detail
Binding
CHEMBL996238
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Inhibition of HIV1 protease
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vitro antiviral activity and cross-resistance profile of PL-100, a novel protease inhibitor of human immunodeficiency virus type 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 10.05 | 10.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 10.85 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 10.47 |
| CHEMBL168640 | PPL-100 | 1.0 | 1 | 10.44 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 10.41 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 10.10 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 9.93 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 9.51 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 8.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL729 | LOPINAVIR | Ki | = | 0.014 | nM | 10.85 |
| CHEMBL163 | RITONAVIR | Ki | = | 0.034 | nM | 10.47 |
| CHEMBL168640 | PPL-100 | Ki | = | 0.036 | nM | 10.44 |
| CHEMBL1163 | ATAZANAVIR | Ki | = | 0.039 | nM | 10.41 |
| CHEMBL114 | SAQUINAVIR | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL116 | AMPRENAVIR | Ki | = | 0.117 | nM | 9.93 |
| CHEMBL584 | NELFINAVIR | Ki | = | 0.306 | nM | 9.51 |
| CHEMBL5483011 | INDINAVIR | Ki | = | 1.945 | nM | 8.71 |