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Assay Detail

CHEMBL996399

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human HeLa cells after 2 days
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis, and biological evaluation of thiophene analogues of chalcones.
Romagnoli R, Baraldi PG, Carrion MD, Cara CL, Cruz-Lopez O, Preti D, Tolomeo M, Grimaudo S, Di Cristina A, Zonta N, Balzarini J, Brancale A, Sarkar T, Hamel E.
Bioorg Med Chem (2008) 16 : 5367 -5376
PubMed 18440234 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 6.02 6.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL494788 1 6.80
CHEMBL498780 1 6.52
CHEMBL505604 1 6.51
CHEMBL523591 1 6.39
CHEMBL497959 1 6.33
CHEMBL522029 1 6.30
CHEMBL498786 1 6.00
CHEMBL498779 1 5.96
CHEMBL227779 1 5.89
CHEMBL495693 1 5.85
CHEMBL495686 1 5.85
CHEMBL493619 1 5.85
CHEMBL523888 1 5.85
CHEMBL497553 1 5.82
CHEMBL525925 1 5.80
CHEMBL496720 1 5.80
CHEMBL525745 1 5.77
CHEMBL190474 1 5.70
CHEMBL227766 1 5.43
CHEMBL494789 1 -
CHEMBL32353 1 -
CHEMBL61998 1 -
CHEMBL188132 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL494788 IC50 = 160.0 nM 6.80
CHEMBL498780 IC50 = 300.0 nM 6.52
CHEMBL505604 IC50 = 310.0 nM 6.51
CHEMBL523591 IC50 = 410.0 nM 6.39
CHEMBL497959 IC50 = 470.0 nM 6.33
CHEMBL522029 IC50 = 500.0 nM 6.30
CHEMBL498786 IC50 = 1000.0 nM 6.00
CHEMBL498779 IC50 = 1100.0 nM 5.96
CHEMBL227779 IC50 = 1300.0 nM 5.89
CHEMBL495693 IC50 = 1400.0 nM 5.85
CHEMBL495686 IC50 = 1400.0 nM 5.85
CHEMBL493619 IC50 = 1400.0 nM 5.85
CHEMBL523888 IC50 = 1400.0 nM 5.85
CHEMBL497553 IC50 = 1500.0 nM 5.82
CHEMBL525925 IC50 = 1600.0 nM 5.80
CHEMBL496720 IC50 = 1600.0 nM 5.80
CHEMBL525745 IC50 = 1700.0 nM 5.77
CHEMBL190474 IC50 = 2000.0 nM 5.70
CHEMBL227766 IC50 = 3700.0 nM 5.43
CHEMBL494789 IC50 > 10000.0 nM -
CHEMBL32353 IC50 > 10000.0 nM -
CHEMBL61998 IC50 > 10000.0 nM -
CHEMBL188132 IC50 > 10000.0 nM -