Assay Detail
Binding
CHEMBL996400
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Inhibition of bovine brain tubulin polymerization for 20 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of thiophene analogues of chalcones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.86 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523591 | — | — | 1 | 6.10 |
| CHEMBL497959 | — | — | 1 | 6.10 |
| CHEMBL498780 | — | — | 1 | 5.96 |
| CHEMBL494788 | — | — | 1 | 5.89 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.85 |
| CHEMBL505604 | — | — | 1 | 5.82 |
| CHEMBL525925 | — | — | 1 | 5.77 |
| CHEMBL495686 | — | — | 1 | 5.70 |
| CHEMBL522029 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL523591 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL497959 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL498780 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL494788 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL505604 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL525925 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL495686 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL522029 | — | IC50 | = | 3000.0 | nM | 5.52 |